血管生成
HIF1A型
癌症研究
缺氧(环境)
转录因子
医学
癌症
缺氧诱导因子
缺氧诱导因子1
生物
基因
癌细胞
生物信息学
内科学
化学
遗传学
有机化学
氧气
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2003-12-01
卷期号:3 (10): 721-732
被引量:6198
摘要
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion. Intratumoral hypoxia and genetic alterations can lead to HIF-1alpha overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics.
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