软骨
组织工程
软骨发生
透明软骨
生物材料
壳聚糖
生物医学工程
软骨细胞
再生(生物学)
材料科学
移植
关节软骨修复
关节软骨
生物相容性
化学
医学
细胞生物学
解剖
骨关节炎
病理
外科
生物
冶金
替代医学
生物化学
作者
Jun‐Kyo Francis Suh,Howard W.T. Matthew
出处
期刊:Biomaterials
[Elsevier]
日期:2000-12-01
卷期号:21 (24): 2589-2598
被引量:1850
标识
DOI:10.1016/s0142-9612(00)00126-5
摘要
Once damaged, articular cartilage has very little capacity for spontaneous healing because of the avascular nature of the tissue. Although many repair techniques have been proposed over the past four decades, none has sucessfully regenerated long-lasting hyaline cartilage tissue to replace damaged cartilage. Tissue engineering approaches, such as transplantation of isolated chondrocytes, have recently demonstrated tremendous clinical potential for regeneration of hyaline-like cartilage tissue and treatment of chondral lesions. As such a new approach emerges, new important questions arise. One of such questions is: what kinds of biomaterials can be used with chondrocytes to tissue-engineer articular cartilage? The success of chondrocyte transplantation and/or the quality of neocartilage formation strongly depend on the specific cell-carrier material. The present article reviews some of those biomaterials, which have been suggested to promote chondrogenesis and to have potentials for tissue engineering of articular cartilage. A new biomaterial, a chitosan-based polysaccharide hydrogel, is also introduced and discussed in terms of the biocompatibility with chondrocytes.
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