Genome-wide atlas of gene expression in the adult mouse brain

脑图谱 计算生物学 生物 基因组 地图集(解剖学) 功能基因组学 基因组学 基因 鉴定(生物学) 图谱 神经科学 遗传学 蛋白质表达 解剖 植物
作者
Ed S. Lein,Michael Hawrylycz,Nancy Ao,Mikael Ayres,Amy Bensinger,Amy Bernard,Andrew F. Boe,Mark S. Boguski,Kevin S. Brockway,Emi J. Byrnes,Lin Chen,Li Chen,Tsuey-Ming Chen,Mei Chi Chin,Jimmy Chong,Brian E. Crook,Aneta Czaplinska,Chinh Dang,Suvro Datta,Nick Dee,Aimee L. Desaki,Tsega Desta,Ellen Diep,Tim Dolbeare,Matthew J. Donelan,Hong‐Wei Dong,Jennifer Dougherty,Ben J. Duncan,Amanda Ebbert,Gregor Eichele,Lili K. Estin,Casey Faber,Benjamin A.C. Facer,R T Fields,Shanna R. Fischer,Tim Fliss,Cliff Frensley,Sabrina N. Gates,Katie J. Glattfelder,Kevin R. Halverson,Matthew R. Hart,John G. Hohmann,Maureen P. Howell,Darren P. Jeung,Rebecca A. Johnson,Paul A. Karr,Reena Kawal,Jolene Kidney,Rachel H. Knapik,Chihchau L. Kuan,James Lake,Annabel R. Laramee,Kirk Larsen,Christopher Lau,Tracy Lemon,Agnes JH Liang,Ying Liu,Lon T. Luong,Jesse Michaels,J. S. Morgan,Rebecca J. Morgan,Marty Mortrud,Nerick F. Mosqueda,Lydia Ng,Randy Ng,Geralyn J. Orta,Caroline C. Overly,Tu H. Pak,Sheana Parry,Dev S. Pathak,Owen C. Pearson,Ralph B. Puchalski,Zackery L. Riley,Hannah R. Rockett,Stephen A. Rowland,Joshua J. Royall,Marcos J. Ruiz,Nadia R. Sarno,Katherine Schaffnit,Nadiya Shapovalova,Taz Sivisay,Cliff Slaughterbeck,Simón C. Smith,Kimberly A. Smith,Bryan I. Smith,Andy J. Sodt,Nick N. Stewart,Kenda-Ruth Stumpf,Susan M. Sunkin,Madhavi Sutram,Angelene Tam,Carey D. Teemer,Christina Thaller,Carol L. Thompson,Lee R. Varnam,Axel Visel,Ray M. Whitlock,Paul Wohnoutka,Crissa K. Wolkey,Victoria Wong,Matthew Wood,Murat Yaylaoglu,Rob Young,Brian L. Youngstrom,Xu Yuan,Bin Zhang,Theresa A. Zwingman,Allan R. Jones
出处
期刊:Nature [Springer Nature]
卷期号:445 (7124): 168-176 被引量:5237
标识
DOI:10.1038/nature05453
摘要

Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
烂漫念文完成签到,获得积分10
刚刚
Roxanne发布了新的文献求助30
1秒前
YSRAHTN完成签到,获得积分10
2秒前
木穹完成签到,获得积分10
2秒前
luca发布了新的文献求助50
5秒前
6秒前
wanci应助doc.wei采纳,获得10
7秒前
Shi完成签到,获得积分10
8秒前
cmy完成签到,获得积分10
10秒前
17秒前
18秒前
Lucas应助科研通管家采纳,获得10
21秒前
脑洞疼应助科研通管家采纳,获得10
21秒前
doc.wei发布了新的文献求助10
21秒前
向日葵应助科研通管家采纳,获得10
21秒前
所所应助科研通管家采纳,获得10
21秒前
酷波er应助科研通管家采纳,获得10
21秒前
SciGPT应助科研通管家采纳,获得10
21秒前
zhi完成签到,获得积分10
21秒前
爆米花应助科研通管家采纳,获得10
21秒前
今后应助科研通管家采纳,获得10
21秒前
李大姐发布了新的文献求助10
23秒前
冯冯冯完成签到 ,获得积分10
23秒前
T123456789完成签到,获得积分10
23秒前
羽宇完成签到,获得积分10
26秒前
万里完成签到,获得积分10
29秒前
小白完成签到,获得积分10
30秒前
双夏完成签到 ,获得积分10
30秒前
独特笙完成签到 ,获得积分10
30秒前
JERRI完成签到,获得积分10
32秒前
32秒前
科研通AI2S应助gdh采纳,获得10
32秒前
情怀应助qing采纳,获得10
34秒前
wangbq发布了新的文献求助10
34秒前
橙子皮完成签到,获得积分10
38秒前
42秒前
爱学习的悦悦子完成签到 ,获得积分10
43秒前
从南到北发布了新的文献求助50
45秒前
冷傲以珊完成签到,获得积分10
45秒前
doc.wei完成签到 ,获得积分10
45秒前
高分求助中
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Very-high-order BVD Schemes Using β-variable THINC Method 568
Chen Hansheng: China’s Last Romantic Revolutionary 500
XAFS for Everyone 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137721
求助须知:如何正确求助?哪些是违规求助? 2788646
关于积分的说明 7787887
捐赠科研通 2445011
什么是DOI,文献DOI怎么找? 1300139
科研通“疑难数据库(出版商)”最低求助积分说明 625814
版权声明 601043