转录因子
NFAT公司
免疫系统
免疫
癌变
调节器
转录调控
癌症
癌症研究
生物
细胞生物学
免疫学
遗传学
基因
作者
Martin Müller,Anjana Rao
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2010-08-20
卷期号:10 (9): 645-656
被引量:529
摘要
Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numerous developmental programmes in vertebrates. Dysregulation of these programmes can lead to malignant growth and cancer. This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights into their potential roles in cancer development.
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