化学
微囊藻毒素
色谱法
串联质谱法
电喷雾电离
质谱法
检出限
电喷雾
电离
分析化学(期刊)
液相色谱-质谱法
蓝藻
离子
生物
有机化学
细菌
遗传学
作者
Lifeng Zhang,Xiaofei Ping,Zhaoguang Yang
出处
期刊:Talanta
[Elsevier]
日期:2004-01-01
卷期号:62 (1): 191-198
被引量:61
标识
DOI:10.1016/j.talanta.2003.07.001
摘要
The need for a rapid, sensitive, and reliable analytical method for microcystin-LR has been emphasized by the awareness of toxic cyanobacteria as a human-health risk through drinking water. Microcystin-LR is the most commonly reported microcystin which is produced by cyanobacteria. The WHO guideline for microcystin-LR in drinking water is 1 μg/l. In this paper, an effective method has been developed by application of high-performance liquid chromatography/tandem electrospray ionization mass detector in the determination of microcystin-LR in surface water sample. At the LC–MS–MS CID–full scan mode, different relative collision energies have been tested with 30% being used for further microcystin-LR analysis. The possible mass dissociation path has been proposed. Based on 30% relative collision energy, present method has an excellent method detection limit (MDL), which is as low as 2.6 ng/l. To the best of our knowledge, this represents one of the most sensitive methods in existence for the microcystin-LR analysis. This method has also been validated by evaluation of the calibration linearity, precision, accuracy, recovery, and mass ratio stability.
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