端粒酶
端粒
医学
RNA剪接
外显子
选择性拼接
端粒酶逆转录酶
基因
病理
生物
遗传学
核糖核酸
作者
Mostafa Behjati‐Ardakani,Mansoor Salehi,Sharareh Moghim,Gholamreza Dashti
标识
DOI:10.2143/ac.62.1.2019364
摘要
There are some lines of evidence about the role of telomeres in atherosclerotic plaque formation and development. Despite the role of telomerase in telomere elongation and protection, its role in atherosclerosis is not fully understood. The present study was designed to evaluate the importance of alternative splicing variants ofTERT (telomerase reverse transcriptase) in the atherosclerosis process.Six Dutch-Polish rabbits were fed a high-cholesterol diet, and six control animals a normal diet. Alternative splicing was assessed by RT-PCR in aortic endothelial cells of these rabbits. Fatty streaks formation was assessed by H & E staining of aortic tissues. There were no significant differences in variants of TERT in control and test animals; neither in endothelial cells nor in aortic vessel wall.Our results demonstrated that a decrease in telomerase activity in atherosclerosis formation is not due to TERT gene alternative splicing.
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