已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Thyroid Remnant 131I Ablation for Papillary and Follicular Thyroid Carcinoma

甲状腺癌 医学 甲状腺 滤泡癌 乳头状癌 烧蚀 卵泡期 病理 内科学
作者
Ernest L. Mazzaferri
出处
期刊:Thyroid [Mary Ann Liebert, Inc.]
卷期号:7 (2): 265-271 被引量:215
标识
DOI:10.1089/thy.1997.7.265
摘要

Outcome was compared in 1,004 patients with differentiated thyroid carcinoma (DTC) who underwent thyroid remnant ablation with 131I (n = 151) or were either treated with thyroid hormone alone (755) or given no postoperative medical therapy (98). Median follow-up time was 18.7 years for patients treated with thyroid hormone alone, 21.3 years for those given no adjunctive medical therapy, and 14.7 years for those treated with thyroid remnant ablation. End points measured were cancer recurrence, development of distant metastases, and death due to thyroid carcinoma. Tumor recurrence was about threefold lower (p < 0.001) and fewer patients developed distant metastases (p < 0.002) after thyroid remnant ablation than after other forms of postoperative treatment, an effect observed only in patients with primary tumors > or = 1.5 cm in diameter. The doses of 131I were stratified into two groups: 29-50 mCi (mean 47 mCi) in 43% and 51-200 mCi (111 mCi) in 57% of patients. Both groups experienced similar recurrence rates (7% and 9%, respectively, p = 0.7). There were fewer cancer deaths after thyroid remnant ablation than after the other treatment strategies (p < 0.001), differences that occurred only in patients aged 40 years or older at the time of initial treatment and with primary tumors > or = 1.5 cm. The variables that influenced cancer recurrence in a Cox proportional hazards model were absence of cervical lymph node metastases (hazards ratio [HR] 0.8), tumor stage (HR 1.8), and treatment of the thyroid remnant (HR 0.9); those that independently affected cancer-specific death rates were age (HR 13.3), recurrence of cancer (16.6), time to treatment (HR 3.5), thyroid remnant ablation (HR 0.5), and tumor stage (HR 2.3). This study suggests that thyroid remnant ablation is effective in reducing recurrence of DTC in patients of all ages and reduces the risk of death from thyroid carcinoma in patients > age 40 at the time of diagnosis. These effects are not apparent in patients with isolated tumors < 1.5 cm that are not metastatic to regional lymph nodes or invading the thyroid capsule. The optimal dose of 131I necessary to achieve this effect remains uncertain.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
香蕉觅云应助爻解采纳,获得10
1秒前
1秒前
李健应助胡林采纳,获得10
3秒前
纸鸢发布了新的文献求助10
3秒前
打打应助科研通管家采纳,获得10
3秒前
3秒前
科研通AI5应助科研通管家采纳,获得10
3秒前
3秒前
orixero应助科研通管家采纳,获得10
3秒前
Smile发布了新的文献求助30
3秒前
利物鸟贝拉完成签到,获得积分10
4秒前
4秒前
hyr发布了新的文献求助10
5秒前
ohh发布了新的文献求助10
5秒前
Lamis完成签到 ,获得积分10
6秒前
17852573662完成签到,获得积分10
6秒前
7秒前
羊绮完成签到,获得积分10
8秒前
犇骉完成签到,获得积分10
8秒前
科目三应助kylin采纳,获得10
9秒前
10秒前
研友_QLXYgn发布了新的文献求助10
11秒前
汉堡包应助小方采纳,获得10
11秒前
12秒前
13秒前
kmkm发布了新的文献求助10
13秒前
乐乐应助快来和姐妹玩采纳,获得30
13秒前
lei完成签到,获得积分10
14秒前
胡林发布了新的文献求助10
16秒前
Smile完成签到,获得积分10
17秒前
李健应助豆豆欢欢乐采纳,获得10
18秒前
徐徐发布了新的文献求助10
19秒前
20秒前
故城完成签到 ,获得积分10
24秒前
墨川完成签到,获得积分10
24秒前
sjxbjrndkd完成签到 ,获得积分10
25秒前
jimi完成签到,获得积分10
26秒前
28秒前
29秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976455
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203850
捐赠科研通 3257210
什么是DOI,文献DOI怎么找? 1798648
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806539