药物输送
材料科学
聚合物
阿霉素
PEG比率
纳米技术
药品
己内酯
纳米颗粒
化学工程
靶向给药
可生物降解聚合物
药理学
聚合
复合材料
化疗
医学
外科
财务
经济
工程类
作者
Yingfeng Tu,Fei Peng,Alain A. M. André,Yongjun Men,Mangala Srinivas,Daniela A. Wilson
出处
期刊:ACS Nano
[American Chemical Society]
日期:2017-02-14
卷期号:11 (2): 1957-1963
被引量:224
标识
DOI:10.1021/acsnano.6b08079
摘要
We report the self-assembly of a biodegradable platinum nanoparticle-loaded stomatocyte nanomotor containing both PEG-b-PCL and PEG-b-PS as a potential candidate for anticancer drug delivery. Well-defined stomatocyte structures could be formed even after incorporation of 50% PEG-b-PCL polymer. Demixing of the two polymers was expected at high percentage of semicrystalline poly(ε-caprolactone) (PCL), resulting in PCL domain formation onto the membrane due to different properties of two polymers. The biodegradable motor system was further shown to move directionally with speeds up to 39 μm/s by converting chemical fuel, hydrogen peroxide, into mechanical motion as well as rapidly delivering the drug to the targeted cancer cell. Uptake by cancer cells and fast doxorubicin drug release was demonstrated during the degradation of the motor system. Such biodegradable nanomotors provide a convenient and efficient platform for the delivery and controlled release of therapeutic drugs.
科研通智能强力驱动
Strongly Powered by AbleSci AI