Copper‐Catalyzed 1,6‐Hydrodifluoroacetylation of para‐Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant

Abstract An original and efficient copper‐catalyzed 1,6‐hydrodifluoroacetylation of para ‐quinone methides with difluoroalkyl bromides has been described with bis(pinacolato)diboron (B 2 pin 2 ) as reductant. In this reaction, a new C( sp 3 )–CF 2 bond is constructed under smart conditions. A broad substrate scope of para ‐quinone methides ( p ‐QMs) make this protocol very practical and attractive. Preliminary mechanistic studies manifested that a difluoroalkyl radical pathway was involved in this reaction. Also the presence of the diboron reagent was an essential requisite in this transformation. magnified image