药物输送
琼脂糖
光热治疗
自愈水凝胶
光热效应
胶体金
纳米颗粒
纳米技术
体内
车辆段
生物医学工程
控制释放
可见光谱
生物物理学
化学
材料科学
聚合物
色谱法
高分子化学
光电子学
医学
复合材料
考古
生物技术
历史
生物
作者
Johan S. Basuki,Fengxiang Qie,Xavier Mulet,Randy Suryadinata,Aditya V. Vashi,Yong Y. Peng,Lingli Li,Xiaojuan Hao,Tianwei Tan,Timothy C. Hughes
标识
DOI:10.1002/anie.201610618
摘要
The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half-life in vivo. Thus there is a need for a drug delivery system that acts as a reservoir and releases the drug remotely "on demand". Here we demonstrate a simple light-triggered local drug delivery system through photo-thermal interactions of polymer-coated gold nanoparticles (AuNPs) inside an agarose hydrogel as therapeutic depot. Localized temperature increase induced by the visible light exposure caused reversible softening of the hydrogel matrix to release the pre-loaded therapeutics. The release profile can be adjusted by AuNPs and agarose concentrations, light intensity and exposure time. Importantly, the biological activity of the released bevacizumab was highly retained. In this study we demonstrate the potential application of this facile AuNPs/hydrogel system for ocular therapeutics delivery through its versatility to release multiple biologics, compatibility to ocular cells and spatiotemporal control using visible light.
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