MDMX公司
膀胱癌
平方毫米
癌症
药物发现
医学
临床试验
癌症研究
生物信息学
药品
计算生物学
药理学
肿瘤科
生物
内科学
抑制器
基因
遗传学
作者
Chiara Ciccarese,Francesco Massari,Ana Blanca,Giampaolo Tortora,Rodolfo Montironi,Liang Cheng,Marina Scarpelli,Maria Rosaria Raspollini,Nuno Vau,Jorge Fonseca,Antonio López-Beltrán
标识
DOI:10.1080/14728222.2017.1297798
摘要
Despite more than 30 years of research on p53 resulting in >50,000 publications, we are now beginning to figure out the complexity of the p53 pathway, gene ontology and conformational structure of the molecule. Recent years brought great advances in p53 related drugs and the potencial ways in which p53 is inactivated in cancer. Areas covered: We searched for related publications on Pubmed and ClinicalTrial.gov using the following keywords 'p53, Tp53, p53 and bladder cancer, p53 and therapeutic target'. Relevant articles improved the understanding on p53 pathways and their potential as candidate to targeted therapy in bladder cancer. Expert opinion: Novel strategies developed to restore the function of mutants with chemical chaperones or by using compounds to improved pharmacokinetic properties are in development with potential to be applied in the oncology clinic. Other strategies targeting aberrantly overexpressed p53 regulators with wild-type p53 are also an active area of research. In particular, studies inhibiting the interaction of p53 with its negative regulators MDMX and MDM2 are an important field in drug discovery. Small molecules for inhibition of MDM2 are now in clinical trials process. However, personalized anticancer therapy might eventually advance through analyses of p53 status in cancer patients.
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