微卫星不稳定性
医学
表阿霉素
内科学
肿瘤科
癌症
围手术期
DNA错配修复
胃肠病学
结直肠癌
化疗
外科
等位基因
微卫星
化学
乳腺癌
基因
生物化学
作者
Elizabeth Smyth,Andrew Wotherspoon,Clare Peckitt,David González,Sanna Hulkki-Wilson,Zakaria Eltahir,Matteo Fassan,Massimo Rugge,Nicola Valeri,Alicia Okines,Madeleine Hewish,William Allum,Sally Stenning,Matthew Nankivell,Ruth E. Langley,David Cunningham
出处
期刊：JAMA Oncology
[American Medical Association]
日期：2017-02-27
卷期号：3 (9): 1197-1197
被引量：444
标识
DOI：10.1001/jamaoncol.2016.6762
摘要
Mismatch repair (MMR) deficiency (MMRD) and microsatellite instability (MSI) are prognostic for survival in many cancers and for resistance to fluoropyrimidines in early colon cancer. However, the effect of MMRD and MSI in curatively resected gastric cancer treated with perioperative chemotherapy is unknown.
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