化学
体内分布
结合
螯合作用
钆
部分
多塔
磁共振成像
磁共振造影剂
组合化学
立体化学
体外
生物化学
有机化学
放射科
医学
数学分析
数学
作者
Ah Rum Baek,Hee‐Kyung Kim,Subin Park,Gang Ho Lee,Hyo Jeung Kang,Jae‐Chang Jung,Joon‐Suk Park,Hunkyu Ryeom,Tae‐Jeong Kim,Yongmin Chang
标识
DOI:10.1021/acs.jmedchem.7b00060
摘要
We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) coordinationn cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging.
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