雷公藤
乙酰胆碱酯酶
化学
立体化学
IC50型
阿切
抗菌活性
内生真菌在植物防御中的应用
真菌
传统医学
酶
生物化学
生物
植物
体外
细菌
替代医学
病理
医学
遗传学
作者
Qiuhong Zhao,Zhong‐Duo Yang,Zong-Mei Shu,Yonggang Wang,Minggang Wang
出处
期刊:PubMed
日期:2016-01-01
卷期号:15 (3): 453-457
被引量:8
摘要
In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (1-9) from Talaromyces genus. In the next step, all compounds were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and antitumor activities. Compound 11 showed moderate anti-monoamine oxidase activity with IC50 value of 61 μM; compounds 3, 4, 8 showed weaker anti-acetylcholinesterase activity; compounds 1, 3, 4, 7, 8, 9 showed moderate antibacterial activities; compounds 7, 8, 9 showed cytotoxicity against B16 cancer cell line with inhibitory rate of 86%, 82%, 78%, respectively, at the concentration of 500 μg/mL.
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