Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients [published erratum appears in Am J Psychiatry 1996 Apr;153(4):588]

血清素 精神科 心理学 萧条(经济学) 响应度 医学 神经科学 内科学 物理 光学 光电探测器 宏观经济学 经济 受体
作者
J. John Mann,Kevin Malone,David J. Diehl,J M Perel,Thomas B. Cooper,Mark A. Mintun
出处
期刊:American Journal of Psychiatry [American Psychiatric Association Publishing]
卷期号:153 (2): 174-182 被引量:184
标识
DOI:10.1176/ajp.153.2.174
摘要

Back to table of contents Previous article Next article No AccessDemonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients [published erratum appears in Am J Psychiatry 1996 Apr;153(4):588]Published Online:1 Apr 2006https://doi.org/10.1176/ajp.153.2.174AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: For over 25 years, it has been hypothesized that major depression is due to a deficiency of available serotonin or subsensitivity of key serotonin receptors in relevant brain regions. Direct evidence supporting this hypothesis has been lacking because of the difficulty in studying regional brain serotonergic function. The authors have developed a method for visualizing in vivo regional brain responses to serotonin release by comparing regional brain glucose metabolism after administration of the serotonin-releasing drug dl- fenfluramine, relative to placebo. METHOD: Results with healthy subjects (N = 6) were compared to those obtained with drug-free inpatients with moderately severe major depression (N = 6). RESULTS: Healthy subjects had several areas of statistically significant increases in metabolism, mostly in the left prefrontal and temporoparietal cortex, and areas of decreased metabolism, such as in the right prefrontal cortex. In contrast, the depressed patients had no areas of increase or decrease in metabolism, differing significantly from healthy subjects. Results with patients resembled those with healthy subjects (N = 10) who were scanned twice without active drug on either occasion. CONCLUSIONS: This study provides the first direct visualization of blunted regional brain responses to serotonin release in the brain of patients with major depression, a finding that supports the hypothesis of impaired serotonergic transmission in depression. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. 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Brown, M.D., Ph.D.1 September 1998 | American Journal of Psychiatry, Vol. 155, No. 9Differences and variability in plasma noradrenaline between depressive and anxiety disorders1 July 2016 | Journal of Psychopharmacology, Vol. 12, No. 2Synapse, Vol. 30, No. 4Cognition & Emotion, Vol. 12, No. 3Journal of Clinical Psychopharmacology, Vol. 18, No. 6Anterior cingulate gyrus volume and glucose metabolism in autistic disorder1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 8A Review of Functional Neuroimaging in Mood Disorders: Positron Emission Tomography and Depression1 June 1997 | The Canadian Journal of Psychiatry, Vol. 42, No. 5Serotonergic modulation of dopamine measured with [11C]raclopride and PET in normal human subjects1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 4Reduced serotonin responsivity in depression7 October 2014 | American Journal of Psychiatry, Vol. 154, No. 3Deteriorated affective disorder a rarity?7 October 2014 | American Journal of Psychiatry, Vol. 154, No. 3Journal of Neural Transmission, Vol. 104, No. 8-9Current Opinion in Psychiatry, Vol. 10, No. 2Annals of the New York Academy of Sciences, Vol. 836, No. 1 Neurobiology Volume 153Issue 2 February 1996Pages 174-182 Metrics PDF download History Published online 1 April 2006 Published in print 1 February 1996

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