药物重新定位
药品
药理学
医学
药物开发
重新调整用途
批准的药物
药物发现
效力
生物信息学
化学
生物
生态学
生物化学
体外
作者
Wei Sun,Philip E.J. Sanderson,Wei Zheng
标识
DOI:10.1016/j.drudis.2016.05.015
摘要
Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tolerated plasma drug concentrations are lower than the required therapeutic drug concentrations. Drug combinations of two or more compounds with different mechanisms of action are an alternative approach to increase the success rate of drug repositioning.
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