米诺环素
小胶质细胞
生物
神经科学
生物信息学
抗生素
药理学
免疫学
遗传学
炎症
作者
Thomas Möller,Frédérique Bard,Anindya Bhattacharya,Knut Biber,Brian Campbell,Elena Dale,Claudia Eder,Li Gan,Gwenn A. Garden,Zoë A. Hughes,Damien D. Pearse,Roland G. W. Staal,Faten A. Sayed,Paul D. Wes,Hendrikus Boddeke
出处
期刊:Glia
[Wiley]
日期:2016-06-01
卷期号:64 (10): 1788-1794
被引量:136
摘要
Minocycline, a second generation broad‐spectrum antibiotic, has been frequently postulated to be a “microglia inhibitor.” A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to “inhibition” of microglia. It is, however, unclear how this “inhibition” is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted. GLIA 2016;64:1788–1794
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