结核分枝杆菌
臭氧分解
化学
立体化学
体外
产量(工程)
脱水
三萜类
分子
有机化学
肺结核
生物化学
医学
材料科学
病理
冶金
作者
И. Е. Смирнова,О. Б. Казакова,Do Thi Thu Huong,E. M. Minnibaeva,А. Н. Лобов,Kiryll Yu. Suponitsky
标识
DOI:10.1177/1934578x1400901005
摘要
A one-pot synthesis of a hybrid triterpenoid-steroid molecule, hollongdione (22,23,24,25,26,27-hexanordammar-3,20-dion), was achieved in a yield of 89%, based on the selective dehydration of dipterocarpol following ozonolysis. The structure of hollongdione was confirmed by X-ray analysis for the first time. Dammar-20(22),24(25)-dien inhibited the growth of Mycobacterium tuberculosis (strain H37Rv) in vitro with a MIC of 50 μg/mL.
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