清脆的
基因组编辑
Cas9
计算生物学
遗传增强
生物
表观遗传学
癌症
基因
生物信息学
遗传学
作者
Minjiang Chen,Aiwu Mao,Min Xu,Qiaoyou Weng,Jianting Mao,Jiansong Ji
标识
DOI:10.1016/j.canlet.2019.01.017
摘要
Cancer is a genetic disease stemming from cumulative genetic/epigenetic aberrations. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated genome editing technology has been extensively applied in various cell types and organisms, both in vitro and in vivo, for efficient gene disruption and gene modification. CRISPR-Cas9 has shown great promise for the treatment of cancer. However, despite its advantages and tremendous potential, numerous challenges, such as fitness of edited cells, editing efficiency, delivery methods and potential off-target effects, remain to be solved for completely clinical application. Here, we present the potential applications and recent advances of CRISPR-Cas9 in cancer therapy, and discuss the challenges that might be encountered in clinical applications.
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