自噬
角膜
圆锥角膜
纤维化
生物
细胞生物学
机制(生物学)
伤口愈合
医学
癌症研究
免疫学
病理
神经科学
遗传学
细胞凋亡
哲学
认识论
作者
Lynn M. Martin,Nallathambi Jeyabalan,Ratnakar Tripathi,Trailokyanath Panigrahi,Philip J. Johnson,Arkasubhra Ghosh,Rajiv R. Mohan
出处
期刊:Ocular Surface
[Elsevier]
日期:2019-04-01
卷期号:17 (2): 186-197
被引量:30
标识
DOI:10.1016/j.jtos.2019.01.008
摘要
Autophagy is a well-conserved self-eating mechanism of cell survival during periods of nutrient deprivation, stress and injury. Autophagy is implicated in many pathophysiological conditions across all organ systems. The cornea is an avascular transparent tissue that is prone to damage by trauma, injury and infection. Following insult, the cornea undergoes a complex wound healing process, which is regulated by multiple factors including autophagy. The involvement of autophagy in keratoconus and HSV-1 infection has been demonstrated, underlining the importance of this mechanism in corneal disorders. However, the role of autophagy in corneal wound repair, fibrosis and angiogenesis is still unclear. Recently, we characterized the expression of autophagy-related genes in cornea and are studying their role in the modulation of corneal conditions including fibrosis and dystrophies. Preliminary results presented within this review article support further investigation of the dynamic modulation of autophagy-related genes in corneal health and disease. This article provides an overview of how autophagy modulates corneal function.
科研通智能强力驱动
Strongly Powered by AbleSci AI