纳米颗粒
纳米技术
纳米生物技术
笼子
化学
生物相容性材料
生物物理学
材料科学
生物医学工程
生物
工程类
结构工程
作者
Boreum Choi,Hansol Kim,Hyun‐Jung Choi,Sebyung Kang
标识
DOI:10.1007/978-981-13-0445-3_2
摘要
Protein cage nanoparticles are made of biomaterials, proteins, and have well-defined cage-like architectures designed and built by nature. They are composed of multiple copies of one or a small number of chemically identical subunits having a highly uniform nano-size and symmetric structure. Protein cage nanoparticles have genetic and chemical plasticity amenable to simultaneously introducing multiple cell-specific targeting ligands, diagnostic agents, and their corresponding therapeutic agents at desired sites depending on its purpose. A wide range of protein cage nanoparticles, such as ferritin, lumazine synthase, encapsulin, and virus-like particles, has been extensively explored and utilized in biomedical fields as effective delivery nanoplatforms of diagnostics and/or therapeutics. Highly biocompatible and plastic protein cage nanoparticles may provide a new paradigm for developing simple, but versatile in vivo delivery systems.
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