Strong and biocompatible poly(lactic acid) membrane enhanced by Ti3C2Tz (MXene) nanosheets for Guided bone regeneration

Herein, strong and biocompatible Ti3C2Tz-enhanced poly(lactic acid) (PLA) nanocomposite membranes were prepared. The interface of the Ti3C2Tz nanosheets with the hydrophobic PLA matrix was mediated using n-octyltriethoxysilane (OTES). The optimized ultimate tensile strength of the OTES-Ti3C2Tz/PLA nanocomposite membrane was 72 MPa (33% higher than that of a pure PLA membrane). The addition of Ti3C2Tz enhanced the biological properties of the membrane, including the in vitro adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 mouse preosteoblasts.