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Development of a Short Questionnaire to Assess the Quality of Life in Crohn’s Disease and Ulcerative Colitis

克朗巴赫阿尔法 医学 生活质量(医疗保健) 溃疡性结肠炎 组内相关 结构效度 炎症性肠病 物理疗法 疾病 心理测量学 内科学 临床心理学 护理部
作者
Laith Alrubaiy,Wai-Yee Cheung,Phedra Dodds,Hayley A Hutchings,Ian Russell,Alan Watkins,John Williams
出处
期刊:Journal of Crohn's and Colitis [Oxford University Press]
卷期号:9 (1): 66-76 被引量:26
标识
DOI:10.1093/ecco-jcc/jju005
摘要

Most of the disease-specific quality of life (QoL) measures for inflammatory bowel disease (IBD) are lengthy and time consuming. None have been established for routine use in clinical practice. We designed this study to develop a short QoL measure in IBD.A 32-item questionnaire, the Crohn's and ulcerative colitis questionnaire (CUCQ)-32 was developed by reviewing the literature of the previously validated questionnaires and by consultation with patients and experts. Construct validity was carried out using the Short Form 12 and the EuroQol 5 dimensions questionnaires and two disease severity measures (the Simple Clinical Colitis Activity Index and the Harvey-Bradshaw Index). Test-retest analysis was done by asking patients to complete the CUCQ questionnaire twice within a period of two weeks.Data were obtained from 205 patients with IBD who completed the CUCQ-32. Psychometric analysis showed that Cronbach's α was 0.88, item-total correlations were good, and there were no ceiling or flooring effects. Stepwise regression identified eight items that accounted for >95% of the variance in the CUCQ-32. The resulting CUCQ-8 demonstrated good internal consistency (Cronbach's α = 0.84), had good reproducibility (intraclass correlation coefficient = 0.94), was well correlated with the EuroQol 5 dimensions questionnaire (r = 0.58) and the Short Form-12 (r = 0.65 for physical component and r = 0.63 for mental component), and was responsive to change (responsiveness ratio was 0.64, p-value < 0.05).CUCQ-8 is a short questionnaire that has the potential to be an efficient tool for assessing the QoL of all patients with IBD in clinical practice.
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