未折叠蛋白反应
内质网
生物
下调和上调
细胞生物学
内质网相关蛋白降解
自噬
平衡
伴侣(临床)
翻译(生物学)
细胞凋亡
基因
生物化学
医学
信使核糖核酸
病理
作者
Lihong Zhao,Susan L. Ackerman
标识
DOI:10.1016/j.ceb.2006.06.005
摘要
Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response (UPR), which induces profound changes in cellular metabolism including general translation attenuation, transcriptional upregulation of molecular chaperone genes, and activation of ER-associated degradation. However, prolonged or acute ER stress results in cell death. Recent progress suggests that ER stress and UPR play key roles in the immune response, diabetes, tumor growth under hypoxic conditions, and in some neurodegenerative diseases. Further research on ER stress and UPR will greatly enhance the understanding of these physiological and pathological processes, and provide novel avenues to potential therapies.
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