New Ergostane and Lanostane from Antrodia Camphorata

Fourteen compounds (one biphenyl, six ergostane, and seven lanostane derivatives) have been isolated from the fruiting body of Antrodia camphorata. They are 3β, 15α-dihydroxylanosta-7, 9 (11), 24-trien-21-oic acid, antcin K, dehydroeburicoic acid, eburicoic acid, methyl antcinate B, methyl antcinate H, zhankuic acid A, zhankuic acid B, dehydrosulphurenic acid, sulphurenic acid, 15α-acetyl-dehydrosulphurenic acid, versisponic acid D, zhankuic acid C, and 2, 2', 5, 5'-tetramethoxy-3, 4, 3', 4'-bis (methlylenedioxy) -6, 6'-dimethylbiphenyl. Among them, two lanostane-type compounds-sulphurenic acid and versisponic acid D were not previously reported from this fungus. 3β, 15α-Dihydroxylanosta-7, 9 (11), 24-trien-21-oic acid and antcin K are first found from nature and their structures were determined by spectroscopic methods.