Hepatocellular carcinoma in hepatectomized patients: biologic and therapeutic implications.

六氯环己烷 肝细胞癌 有丝分裂 新生血管 细胞凋亡 病理 医学 癌症研究 肝切除术 有丝分裂指数 内科学 血管生成 肿瘤科 生物 胃肠病学 外科 切除术 细胞生物学 生物化学
作者
Thomas Makatsoris,Theodore Petsas,Athanassios C. Tsamandas,N Pagoni,Zafiria G Papathanassiou,Dionissios Karavias,Chrisoula Karatza,Dimitrios Kardamakis,Haralabos Kalofonos
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期刊:PubMed 卷期号:25 (4): 3067-73
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The macroscopic and microscopic features of 60 hepatocellular carcinomas (HCC) were investigated and correlated with patients' disease-free survival.The study included 60 HCCs removed, by partial hepatectomy, from an equal number of patients. In these tumors, several macroscopic and microscopic features were assessed, graded and correlated with disease-free survival.HCCs begin as small, well-differentiated tumors that have an increased proliferation rate and neovascularization. Vascular invasion, which is the strongest predictor of disease recurrence, correlated significantly with tumor number and size, the predominant and worst degree of differentiation, and the apoptosis/mitosis ratio. In the absence of macroscopic or large vessel invasion, the largest tumor size (p = 0.006), apoptosis/mitosis ratio (p = 0.03) and number of tumors (p = 0.04) were independent predictors of disease-free survival.This study showed that, in humans, the prognosis of HCC depends on several biological factors. Aggressive biological behavior (vascular invasion and recurrence) correlated significantly with: a) alterations in the apoptosis/mitosis ratio and b) architectural and cellular alterations.

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