纳米医学
肿瘤微环境
癌症
肿瘤异质性
计算生物学
医学
肿瘤细胞
癌症治疗
纳米技术
癌症研究
生物信息学
生物
内科学
材料科学
纳米颗粒
作者
Bárbara B. Mendes,Diana P. Sousa,João Conniot,João Conde
标识
DOI:10.1016/j.trecan.2021.05.001
摘要
The interest in nanomedicine for cancer theranostics has grown significantly over the past few decades. However, these nanomedicines need to overcome several physiological barriers intrinsic to the tumor microenvironment (TME) before reaching their target. Intrinsic tumor genetic/phenotypic variations, along with intratumor heterogeneity, provide different cues to each cancer type, making each patient with cancer unique. This brings additional challenges in translating nanotechnology-based systems into clinically reliable therapies. To develop efficient therapeutic strategies, it is important to understand the dynamic interactions between TME players and the complex mechanisms involved, because they constitute invaluable targets to dismantle tumor progression. In this review, we discuss the latest nanotechnology-based strategies for cancer diagnosis and therapy as well as the potential targets for the design of future anticancer nanomedicines.
科研通智能强力驱动
Strongly Powered by AbleSci AI