超分子聚合物
材料科学
化学工程
超分子组装
组合化学
生物相容性材料
作者
Alexandra Brito,Salma Kassem,R. L. Reis,Rein V. Ulijn,Ricardo A. Pires,Iva Pashkuleva
出处
期刊:Chem
[Elsevier]
日期:2021-05-24
卷期号:7 (11): 2943-2964
被引量:4
标识
DOI:10.1016/j.chempr.2021.04.011
摘要
Summary Carbohydrate-containing biopolymers such as glycoproteins, proteoglycans, and glycolipids are an incredibly diverse and complex set of natural building blocks used by biological systems to endorse a wide range of molecular functions that are critical to life processes. Simplified synthetic analogs of these polymeric glycoconjugates can capture some of these functions and are increasingly exploited toward the development of supramolecular biomaterials. These carbohydrate amphiphiles can mimic structural aspects through cooperative molecular self-assembly or target distinct signaling pathways through engineered (multivalent) interactions with biological systems. Herein, we discuss the supramolecular principles that regulate the glycome function(s) and the translation of these in the design of supramolecular biomaterials in which carbohydrates are used as information-rich structural elements with huge potential as therapeutic supramolecular biomaterials.
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