Cryoablation Without Excision for Low-Risk Early-Stage Breast Cancer: 3-Year Interim Analysis of Ipsilateral Breast Tumor Recurrence in the ICE3 Trial

医学 低温消融 外科肿瘤学 乳腺癌 中期分析 不利影响 乳房外科 内科学 肿瘤科 随机对照试验 外科 癌症 烧蚀
作者
Richard E. Fine,Richard Gilmore,Jill R. Dietz,Susan K. Boolbol,Michael P. Berry,Linda Han,Andrew S. Kenler,Michael S. Sabel,Kenneth R. Tomkovich,Noam A. VanderWalde,Margaret Chen,Karen S. Columbus,Lisa D. Curcio,Sheldon Feldman,Linsey Gold,Lydia Hernandez,Eric R. Manahan,Susan A. Seedman,Rashmi P. Vaidya,Alexander Sevrukov,Hussein D. Aoun,Randy Hicks,Rache M. Simmons
出处
期刊:Annals of Surgical Oncology [Springer Nature]
卷期号:28 (10): 5525-5534 被引量:85
标识
DOI:10.1245/s10434-021-10501-4
摘要

The ICE3 trial is designed to evaluate the safety and efficacy of breast cryoablation, enabling women older than 60 years with low-risk early-stage breast cancers to benefit from a nonsurgical treatment and to avoid the associated surgical risks. The ICE3 trial is a prospective, multi-center, single-arm, non-randomized trial including women age 60 years or older with unifocal, ultrasound-visible invasive ductal carcinoma size 1.5 cm or smaller and classified as low to intermediate grade, hormone receptor (HR)-positive, and human epidermal growth factor receptor 2 (HER2)-negative. Ipsilateral breast tumor recurrence (IBTR) at 5 years was the primary outcome. A 3-year interim analysis of IBTR was performed, and the IBTR probability was estimated using the Kaplan-Meier method. Full eligibility for the study was met by 194 patients, who received successful cryoablation per protocol. The mean age was 75 years (range, 55–94 years). The mean tumor length was 8.1 mm (range, 8–14.9 mm), and the mean tumor width was 7.4 mm (range, 2.8–14 mm). During a mean follow-up period of 34.83 months, the IBTR rate was 2.06% (4/194 patients). Device-related adverse events were reported as mild in 18.4% and moderate in 2.4% of the patients. No severe device-related adverse events were reported. More than 95% of the patients and 98% of the physicians reported satisfaction with the cosmetic results at the clinical follow-up evaluation. Breast cryoablation presents a promising alternative to surgery while offering the benefits of a minimally invasive procedure with minimal risks. Further study within a clinical trial or registry is needed to confirm cryoablation as a viable alternative to surgical excision for appropriately selected low-risk patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李健应助瞒总采纳,获得10
1秒前
wanci应助外向跳跳糖采纳,获得10
1秒前
3秒前
3秒前
3秒前
一一应助李博士采纳,获得30
3秒前
李健应助禾下乘凉采纳,获得10
3秒前
3秒前
zwd发布了新的文献求助10
4秒前
cdgbdfbsfdvsd发布了新的文献求助30
4秒前
孤独聪健完成签到,获得积分10
4秒前
4秒前
李爱国应助小党打地鼠采纳,获得10
5秒前
7秒前
田様应助飞飛飝采纳,获得10
7秒前
CipherSage应助rosy采纳,获得10
8秒前
小城发布了新的文献求助10
8秒前
8秒前
8秒前
8秒前
10秒前
烟花应助御坂延珠采纳,获得10
10秒前
77seven发布了新的文献求助10
10秒前
怕黑谷波发布了新的文献求助10
11秒前
百浪多息发布了新的文献求助10
11秒前
12秒前
lhyxz完成签到,获得积分20
13秒前
wade2016发布了新的文献求助10
13秒前
赘婿应助浅是宝贝采纳,获得10
14秒前
一一应助emo的哈哈哈采纳,获得10
14秒前
14秒前
充电宝应助百浪多息采纳,获得10
16秒前
打工仔完成签到 ,获得积分10
17秒前
123发布了新的文献求助10
17秒前
瞒总发布了新的文献求助10
17秒前
18秒前
18秒前
ZJFL发布了新的文献求助10
19秒前
充电宝应助cdgbdfbsfdvsd采纳,获得10
19秒前
大个应助飞飛飝采纳,获得10
19秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3252120
求助须知:如何正确求助?哪些是违规求助? 2894918
关于积分的说明 8284229
捐赠科研通 2563608
什么是DOI,文献DOI怎么找? 1391769
科研通“疑难数据库(出版商)”最低求助积分说明 651925
邀请新用户注册赠送积分活动 628951