Association of serum Gasdermin D with anti‐N‐methyl‐D‐aspartate receptor encephalitis

脑炎 自身免疫性脑炎 医学 改良兰金量表 内科学 免疫学 NMDA受体 胃肠病学 受体 内分泌学 病毒 缺血 缺血性中风
作者
Xiaoyu Ma,Chen Chen,Yaxin Lu,Ling Fang,Bin Cao,Xueqiang Hu,Wei Qiu,Yaqing Shu
出处
期刊:Journal of Neurochemistry [Wiley]
卷期号:159 (5): 923-930 被引量:3
标识
DOI:10.1111/jnc.15497
摘要

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease of the central nervous system. Gasdermin D (GSDMD) is associated with autoimmune disorders and neuroinflammatory disorders, but its role in anti-NMDAR encephalitis is unclear. In this study, we measured serum levels of GSDMD in 42 patients with anti-NMDAR encephalitis and 25 healthy controls. Of the 42 patients, 17 had follow-up evaluation of GSDMD levels and modified Rankin scale (mRS) scores at 3 months. Association of GSDMD with anti-NMDAR encephalitis and its clinical parameters were evaluated. Serum GSDMD levels were significantly higher in patients with anti-NMDAR encephalitis than in healthy controls (p = 0.002, padjusted = 0.009), especially in males (p = 0.001, padjusted = 0.022). This was also evident in patients with severe impairment (mRS >3 vs mRS ≤3; p < 0.001). Serum GSDMD was associated with mRS before and after adjustment for age and gender (r = 0.440 and 0.430, p = 0.004 and 0.006, respectively) as well as serum CH50 (r = -0.419 and -0.426, p = 0.011 and 0.012, respectively). Furthermore, 3-month follow-up evaluation revealed that after treatment, anti-NMDAR encephalitis patients had significantly decreased serum GSDMD levels (p = 0.007) and significantly decreased mRS scores (p = 0.002) compared with before treatment. Furthermore, the changes in mRS scores were negatively associated with changes in GSDMD levels, although the associations were not significant (r = -0.222, p = 0.393). Our findings show that serum GSDMD levels are elevated in anti-NMDAR encephalitis and are associated with disease prognosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
壮观的谷冬完成签到 ,获得积分0
刚刚
和谐曼凝完成签到 ,获得积分10
3秒前
如意竺完成签到,获得积分10
3秒前
fzd完成签到,获得积分10
5秒前
8秒前
livra1058完成签到,获得积分10
9秒前
HAO完成签到,获得积分10
11秒前
震动的沉鱼完成签到 ,获得积分10
12秒前
糕糕发布了新的文献求助40
13秒前
dyk完成签到,获得积分10
13秒前
15秒前
carryxu完成签到,获得积分10
15秒前
卡卡罗特应助谦让小蚂蚁采纳,获得10
15秒前
大个应助缓慢醉卉采纳,获得10
16秒前
lzhgoashore完成签到,获得积分10
16秒前
16秒前
helpme完成签到,获得积分10
16秒前
DLY完成签到,获得积分10
17秒前
18秒前
18秒前
达笙完成签到 ,获得积分10
19秒前
研友_VZG7GZ应助炒鸡小将采纳,获得10
21秒前
闪闪山柳完成签到 ,获得积分10
21秒前
在水一方应助科研通管家采纳,获得10
22秒前
小二郎应助科研通管家采纳,获得10
22秒前
852应助科研通管家采纳,获得10
22秒前
小马甲应助科研通管家采纳,获得10
22秒前
zzz发布了新的文献求助10
22秒前
wumiao_1应助科研通管家采纳,获得10
22秒前
wumiao_1应助科研通管家采纳,获得10
22秒前
在水一方应助科研通管家采纳,获得10
22秒前
传奇3应助科研通管家采纳,获得10
22秒前
22秒前
23秒前
23秒前
23秒前
小蘑菇应助科研通管家采纳,获得10
23秒前
在水一方应助科研通管家采纳,获得10
23秒前
23秒前
23秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029