A novel composite of conductive metal organic framework and molecularly imprinted poly (ionic liquid) for highly sensitive electrochemical detection of bisphenol A

A novel composite of conductive metal organic framework and molecularly imprinted poly (ionic liquid) (CMOF-MIPIL) was prepared for highly sensitive detection of bisphenol A (BPA). Ni-based CMOFs with various organic ligands, i.e., 2,3,6,7,10,11-hexaiminotriphenylene, hexa-aminobenzene, and 2,3,6,7,10,11-hexahydroxytriphenylene were synthesized. The electrochemical properties of the obtained Ni-based CMOFs were investigated. The results demonstrated that Ni3(HITP)2 had the highest conductivity and largest effective surface area. CMOF-MIPIL was then prepared with Ni3(HITP)2 as supporter, BPA as template, and ILs as monomer and cross-linker. Under optimal conditions, CMOF-MIPIL sensor exhibited a linear range of BPA detection from 0.005 to 5.0 μM. The detection limit was 4.0 nM. Compared with MIPIL, Ni3(HITP)2, and CMOF-NIPIL-based sensors, the performance of this sensor for BPA detection was superior due to the excellent conductivity and the presence of specific recognition sites. In addition, CMOF-MIPIL sensor had excellent selectivity for BPA. The proposed assay was used for detection of BPA in environmental water samples, plastic bottle and fresh liquid milk samples with success.