哈卡特
角质形成细胞
蛋白激酶B
PI3K/AKT/mTOR通路
银屑病
细胞凋亡
细胞生物学
基因沉默
癌症研究
信号转导
化学
生物
免疫学
生物化学
体外
基因
作者
Rui Zhang,Ye Hua Wang,Xin Shi,Jiang Ji,Fu Qin Zhan,Hong Leng
出处
期刊:Life Sciences
[Elsevier BV]
日期:2021-05-15
卷期号:278: 119630-119630
被引量:15
标识
DOI:10.1016/j.lfs.2021.119630
摘要
Sortilin is found to regulate proliferation and death of different cells, while its role in regulating keratinocyte proliferation and apoptosis is still unknown. In this study, we found that sortilin levels significantly increased in psoriasis patients, and sortilin suppression eliminated the proliferation of HaCaT cells induced by M5 cocktail solution and enhanced the levels of cleaved caspase 3 protein and the Bax/Bcl-2 ratio; however, levels of p-PI3K and p-AKT were decreased. In addition, sortilin silencing remitted the characteristic changes associated with psoriasis-like skin lesions. In summary, suppressed sortilin expression helped inhibit keratinocyte proliferation in HaCaT cells by inactivating PI3K/AKT signaling, which provides a new target for the therapy of psoriasis.
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