Construction of Quaternary Centers Bearing Both Trifluoromethyl and Phosphorus Substituents Based on Base Catalyzed 1,6-Hydrophosphonylation of δ-CF3 Substituted p-Quinone Methides

A NaOtBu catalyzed direct 1,6-hydrophosphonylation of δ-aryl-δ-CF3 substituted p-QMs with diarylphosphine oxides has been described. A broad range of different electronic and steric substituted p-QMs and diarylphosphine oxides were well tolerated under the optimized conditions, furnishing a series of quaternary α-trifluoromethyl substituted phosphonates derivatives in high efficiency. A NaOtBu catalyzed direct 1,6-hydrophosphonylation of δ-aryl-δ-CF3 substituted p-QMs with diarylphosphine oxides has been described. A broad range of different electronic and steric substituted p-QMs and diarylphosphine oxides were well tolerated under the optimized conditions, furnishing a series of quaternary α-trifluoromethyl substituted phosphonates derivetives in high efficiency.