熊果酸
一氧化氮
药理学
炎症
体内
组胺
关节炎
内生
活性氮物种
化学
医学
免疫学
生物化学
生物
内科学
生物技术
色谱法
作者
Qingguo Meng,Ming-Zhu Luan,Huiyun Wang,Jiazhen Wang,Xiaofan Zhang,Fenglan Zhao,Zongliang Liu
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2022-02-01
卷期号:22 (3): 422-436
被引量:28
标识
DOI:10.2174/1389557521666210913113522
摘要
: In vivo and in vitro studies reveal that Ursolic Acid (UA) is able to counteract endogenous and exogenous inflammatory stimuli and has favorable anti-inflammatory effects. The antiinflammatory mechanisms mainly include decreasing the release of histamine in mast cells, suppressing the activities of lipoxygenase, cyclooxygenase and phospholipase, and reducing the production of nitric oxide and reactive oxygen species, blocking the activation of the signal pathway, downregulating the expression of inflammatory factors, and inhibiting the activities of elastase and complement. These mechanisms can open up new avenues for the scientific community to develop or improve novel therapeutic approaches to tackle inflammatory diseases, such as arthritis, atherosclerosis, neuroinflammation, liver diseases, kidney diseases, diabetes, dermatitis, bowel diseases, cancer. The anti-inflammatory activity, the anti-inflammatory mechanism of ursolic acid and its therapeutic applications are reviewed in this paper.
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