医学
膀胱癌
PD-L1
免疫系统
阶段(地层学)
癌症
肿瘤科
疾病
癌症研究
免疫疗法
内科学
免疫组织化学
免疫学
生物
古生物学
作者
Qiaofeng Zhong,Jianzhong Shou,Jianming Ying,Yun Ling,Yue Yu,Zhirong Shen,Yun Zhang,Ning Li,Yuankai Shi,Aiping Zhou
出处
期刊:Future Oncology
[Future Medicine]
日期:2021-08-01
卷期号:17 (22): 2893-2905
被引量:8
标识
DOI:10.2217/fon-2021-0092
摘要
Aims: To explore the prognostic value of high PD-L1 expression on tumor cells (TC) and tumor-infiltrating immune cells (TIIC) in urothelial carcinoma (UC). Patients & methods: 162 UC specimens were evaluated for PD-L1 expression on TIIC and TC with the SP263 assay. High PD-L1 expression was defined as ≥25% staining. Results: High PD-L1 expression on TC in UC patients with stage T1-4 disease was associated with poor overall survival. However, high PD-L1 expression on TIIC in UC patients with stage T1-4 disease revealed favorable disease-free and overall survival; more significant differences were observed in patients with stages T2-4. Multivariate analysis revealed that high PD-L1 expression on TIIC was an independent prognostic predictor for better disease-free and overall survival. Conclusion: High PD-L1 expression on TIIC, but not on TC, is a favorable prognostic factor in UC.Lay abstract Bladder cancer is the tenth most common form of cancer worldwide, and urothelial carcinoma is the most common type of bladder cancer. PD-L1 is a protein that can be expressed on the surface of many tissue types, including tumor cells (TC) and tumor-infiltrating immune cells (TIIC). PD-L1 can help the tumor evade the body’s natural immune defense system. The expression of PD-L1 not only related to the response of immunotherapy but is also associated with the prognosis in bladder cancer. However, the prognostic significance of PD-L1 expression on TC and TIIC remains controversial. This study drew a conclusion that high PD-L1 expression on TIIC, but not on TC, is a favorable prognostic factor in urothelial carcinoma.
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