Micro-galvanic effects of silver-containing titanium implants regulate the immune responses via activating voltage-gated calcium channels in macrophages

分泌物 细胞生物学 生物物理学 材料科学 间充质干细胞 蛋白激酶C 化学 免疫系统 信号转导 生物化学 免疫学 生物 冶金
作者
Lan Chen,Donghui Wang,Xingdan Liu,Bangcheng Yan,Haifeng Zhang,Xianming Zhang,Yuqin Qiao,Jiajun Qiu,Xuanyong Liu
出处
期刊:Chemical Engineering Journal [Elsevier BV]
卷期号:428: 131068-131068 被引量:3
标识
DOI:10.1016/j.cej.2021.131068
摘要

To explore the physiological mechanism of silver for the clinical application of silver-containing biomaterials and biomedical devices, the plasma immersion ion implantation method was used to prepare silver-doped titanium samples in this work. The findings disclosed that with the increase of the introduced Ag amount, the micro-galvanic effects formed by silver and the titanium matrix became stronger, which could stimulate the opening of voltage-gated calcium channels in macrophages to facilitate Ca2+ influx. The increase of intracellular Ca2+ concentration could induce macrophages to polarize towards the M1 phenotype by activating the Ca2+-dependent PKC-NF-κB signaling pathway, while it was more favorable to the polarization of M2 macrophages by improving the synthesis and secretion of calcium-dependent PGE2. Therefore, with the increase of Ag amount, the micro-galvanic effect was enhanced, and the anti-inflammatory responses of macrophages on samples were improved. Furthermore, the co-cultured bone marrow mesenchymal stem cells could inhibit the Ca2+ influx of the co-cultured macrophages to down-regulate the Ca2+-dependent PKC-NF-κB signaling pathway in macrophages and secrete PGE2 to promote the polarization of M2 macrophages, which weaken the inflammatory response. Our results indicate that the immune response can be regulated by the micro-galvanic effects of silver and titanium matrix, and provide new insights into designing and developing the silver-containing biomaterials with a desirable biological response.
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