Progress in the Synthesis of Benzoheterocycles from 2-Halobenzamides

Owing to important pharmacological and biological activities of benzoheterocyclic compounds, their exploration for efficient synthesis methods in drug field is of great value and wide application.Due to the existence of multiple functional groups and reaction sites, great progress has been made in the synthesis of quinazolinones, isoquinolinones, isoindolinones, benzisothiazolones and other benzoheterocyclic compounds using 2-halobenzamides as important synthons.In view of this, according to the different structures of the products, the research progress in the synthesis of benzoheterocyclic compounds with 2-halobenzamides as the starting material in recent 10 years is summarized, and the related reaction mechanism is expounded.