平衡
加压素
神经科学
新皮层
脑血流
加压素受体
河豚毒素
运动前神经元活动
敌手
生物
化学
医学
内科学
受体
内分泌学
作者
Ranjan K. Roy,Ferdinand Althammer,Alexander J. Seymour,Wenting Du,Vinicia C. Biancardi,Jordan P. Hamm,Jessica A. Filosa,Colin H. Brown,Javier E. Stern
出处
期刊:Cell Reports
[Elsevier]
日期:2021-11-01
卷期号:37 (5): 109925-109925
被引量:23
标识
DOI:10.1016/j.celrep.2021.109925
摘要
Neurovascular coupling (NVC), the process that links neuronal activity to cerebral blood flow changes, has been mainly studied in superficial brain areas, namely the neocortex. Whether the conventional, rapid, and spatially restricted NVC response can be generalized to deeper and functionally diverse brain regions remains unknown. Implementing an approach for in vivo two-photon imaging from the ventral surface of the brain, we show that a systemic homeostatic challenge, acute salt loading, progressively increases hypothalamic vasopressin (VP) neuronal firing and evokes a vasoconstriction that reduces local blood flow. Vasoconstrictions are blocked by topical application of a VP receptor antagonist or tetrodotoxin, supporting mediation by activity-dependent, dendritically released VP. Salt-induced inverse NVC results in a local hypoxic microenvironment, which evokes positive feedback excitation of VP neurons. Our results reveal a physiological mechanism by which inverse NVC responses regulate systemic homeostasis, further supporting the notion of brain heterogeneity in NVC responses.
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