化学
烯烃
钴
分子内力
区域选择性
催化作用
甲烷氧化偶联
亚甲基
亚砜
药物化学
有机化学
作者
Yue Shi,Xuefeng Xu,Xinfeng Chen,Wenchao Gao,Xu Zhang
标识
DOI:10.1021/acs.joc.1c01900
摘要
A unique method for the synthesis of cyclopentenes and cyclohexenes has been achieved by the coupling of diketones and alkenes under cobalt(II) catalysis and dimethyl sulfoxide involvement. Under optimal conditions, the formation of five- and six-membered rings can be readily controlled by the α-position substitution of styrenes. This process is proposed to proceed through a reaction sequence of oxidative coupling (mediated by K2S2O8), regioselective alkene insertion (promoted by cobalt), and intramolecular attack of the resulting allylcobalt species on the carbonyl group or methyl group in the reactive methylene process.
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