Objective validity of patient‐reported symptoms in aspirin‐exacerbated respiratory disease patients

Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and acute respiratory symptoms following exposure to aspirin and other cyclooxygenase-1 inhibiting nonsteroidal anti-inflammatory drugs (NSAIDs). Patients with AERD often have a high symptom burden and more severe and difficult-to-treat upper respiratory symptoms compared to patients with aspirin-tolerant CRSwNP.1.