磺酰
化学
亚硫酸
烷基化
激进的
烷基
有机化学
组合化学
药物化学
催化作用
作者
Himangsu Sekhar Dutta,Gulraız Ahmad,Afsar Ali Khan,Mohit Kumar,Raziullah,Dipankar Koley
标识
DOI:10.1002/adsc.201901212
摘要
Abstract A metal‐free domino multicomponent reaction for the direct C−H benzylation and alkylation of quinoxalin‐2(1 H )‐ones using alkenes is described. Triggered by the sulfonyl radical generated from sulfinic acid, the alkenes are transformed to alkyl radicals that react exclusively at the C‐3 position of quinoxalin‐2(1 H )‐ones. Importantly, the method not only functionalizes medicinally important quinoxalin‐2(1 H )‐one scaffold, but also furnishes diverse medicinally relevant sulfones in good to excellent yields under mild conditions. magnified image
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