已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

The Learning Curve Associated with the Administration of Intra-Articular Liposomal Bupivacaine for Total Knee Arthroplasty: A Pilot Study.

医学 渗透(HVAC) 布比卡因 麻醉 类阿片 吗啡 关节置换术 局部麻醉剂 可视模拟标度 全膝关节置换术 外科 内科学 热力学 物理 受体
作者
Anton Khlopas,Randa K. Elmallah,Morad Chughtai,George Yakubek,Mhamad Faour,Alison K. Klika,Carlos A. Higuera,Robert M. Molloy,Michael W. Kattan
出处
期刊:PubMed 卷期号:30: 314-320 被引量:12
链接
标识
摘要

Liposomal bupivacaine is a long-acting, local, injectable anesthetic that is used to potentially mitigate post-operative pain after total knee arthroplasty (TKA). In addition, it may reduce opioid use in the post-operative period and shorten lengths-of-stay (LOS). There have been mixed results in the literature with regards to its efficacy, which raises questions regarding the injection technique used. Therefore, we evaluated the learning curve associated with injection techniques prior to, and after, formal teaching. Specifically, we compared differences in: 1) opioid use; 2) LOS; 3) pain intensity; and 4) discharge disposition in patients who did not receive liposomal bupivacaine (no infiltration cohort), received liposomal bupivacaine with less optimal technique (subpar infiltration), and received liposomal bupivacaine with appropriate technique (optimal infiltration) during their primary TKA.A 1:1:1 ratio of 54 consecutive cases of patients who had no liposomal bupivacaine infiltration, those who had subpar infiltration, and those who had optimal infiltration were included. To evaluate opioid use, the dosages were obtained and converted to their respective morphine milliequivalents (mEq). The total mEq usage was obtained for the day of surgery through post-operative day (POD) 3. LOS was recorded in days. Pain scores were calculated using the visual analogue scale (VAS), obtained from the first post-operative physical therapy note. Discharge status was recorded as discharged to home or rehabilitation. We used an ANOVA test for continuous and X2-square test for categorical variables.When compared to patients who had no infiltration, patients who had subpar infiltration had significantly lower opioid use on day 0, while patients who had optimal infiltration had lower opioid use on post-operative day (POD) 0 and 3. When comparing techniques, opioid use was lower on day 3 for patients who had optimal, as compared to subpar technique. However, LOS and VAS were not significantly different among the three groups. The rehab discharge rate was lower for patients who had optimal as compared to subpar technique.There is a learning curve associated with liposomal bupivacaine use, and incorporating an appropriate technique can markedly affect post-operative outcomes. This should be taken into account when evaluating the potential benefits of this peri-articular injection. It appears that liposomal bupivacaine may decrease opioid use and pain scores when optimal infiltration techniques are used.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
不能随便完成签到,获得积分10
1秒前
2秒前
寻道图强应助科研通管家采纳,获得50
2秒前
打打应助科研通管家采纳,获得10
2秒前
加菲丰丰应助科研通管家采纳,获得20
2秒前
miqiqi完成签到,获得积分10
7秒前
Vivian完成签到 ,获得积分10
7秒前
科研通AI2S应助kjding采纳,获得10
12秒前
16秒前
kid1912应助Alanni采纳,获得10
17秒前
奋斗慕凝完成签到 ,获得积分10
24秒前
33秒前
甜甜的以筠完成签到 ,获得积分10
33秒前
36秒前
大钊gg发布了新的文献求助20
38秒前
39秒前
123发布了新的文献求助10
40秒前
HelenZ发布了新的文献求助10
40秒前
42秒前
chenwei完成签到,获得积分10
44秒前
谢小盟完成签到 ,获得积分10
47秒前
50秒前
jjj完成签到,获得积分10
51秒前
54秒前
55秒前
万能图书馆应助夏木夏采纳,获得30
1分钟前
可爱的函函应助Titanichan采纳,获得10
1分钟前
懦弱的吐司完成签到 ,获得积分10
1分钟前
清森完成签到 ,获得积分10
1分钟前
1分钟前
SciGPT应助仙布着急采纳,获得10
1分钟前
SciGPT应助橘子采纳,获得10
1分钟前
神经哇完成签到,获得积分10
1分钟前
1分钟前
小昕思完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
Www完成签到,获得积分10
1分钟前
大学生完成签到 ,获得积分10
1分钟前
llk完成签到 ,获得积分10
1分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196586
求助须知:如何正确求助?哪些是违规求助? 2845304
关于积分的说明 8053943
捐赠科研通 2509944
什么是DOI,文献DOI怎么找? 1342121
科研通“疑难数据库(出版商)”最低求助积分说明 639320
邀请新用户注册赠送积分活动 608622