已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

The Learning Curve Associated with the Administration of Intra-Articular Liposomal Bupivacaine for Total Knee Arthroplasty: A Pilot Study.

医学 渗透(HVAC) 布比卡因 麻醉 类阿片 吗啡 关节置换术 局部麻醉剂 可视模拟标度 全膝关节置换术 外科 内科学 热力学 物理 受体
作者
Anton Khlopas,Randa K. Elmallah,Morad Chughtai,George Yakubek,Mhamad Faour,Alison K. Klika,Carlos A. Higuera,Robert M. Molloy,Michael W. Kattan
出处
期刊:PubMed 卷期号:30: 314-320 被引量:12
链接
标识
摘要

Liposomal bupivacaine is a long-acting, local, injectable anesthetic that is used to potentially mitigate post-operative pain after total knee arthroplasty (TKA). In addition, it may reduce opioid use in the post-operative period and shorten lengths-of-stay (LOS). There have been mixed results in the literature with regards to its efficacy, which raises questions regarding the injection technique used. Therefore, we evaluated the learning curve associated with injection techniques prior to, and after, formal teaching. Specifically, we compared differences in: 1) opioid use; 2) LOS; 3) pain intensity; and 4) discharge disposition in patients who did not receive liposomal bupivacaine (no infiltration cohort), received liposomal bupivacaine with less optimal technique (subpar infiltration), and received liposomal bupivacaine with appropriate technique (optimal infiltration) during their primary TKA.A 1:1:1 ratio of 54 consecutive cases of patients who had no liposomal bupivacaine infiltration, those who had subpar infiltration, and those who had optimal infiltration were included. To evaluate opioid use, the dosages were obtained and converted to their respective morphine milliequivalents (mEq). The total mEq usage was obtained for the day of surgery through post-operative day (POD) 3. LOS was recorded in days. Pain scores were calculated using the visual analogue scale (VAS), obtained from the first post-operative physical therapy note. Discharge status was recorded as discharged to home or rehabilitation. We used an ANOVA test for continuous and X2-square test for categorical variables.When compared to patients who had no infiltration, patients who had subpar infiltration had significantly lower opioid use on day 0, while patients who had optimal infiltration had lower opioid use on post-operative day (POD) 0 and 3. When comparing techniques, opioid use was lower on day 3 for patients who had optimal, as compared to subpar technique. However, LOS and VAS were not significantly different among the three groups. The rehab discharge rate was lower for patients who had optimal as compared to subpar technique.There is a learning curve associated with liposomal bupivacaine use, and incorporating an appropriate technique can markedly affect post-operative outcomes. This should be taken into account when evaluating the potential benefits of this peri-articular injection. It appears that liposomal bupivacaine may decrease opioid use and pain scores when optimal infiltration techniques are used.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
PONY发布了新的文献求助10
1秒前
meng发布了新的文献求助10
2秒前
3秒前
cc0514gr完成签到,获得积分10
4秒前
寂寞的寄文完成签到 ,获得积分10
6秒前
赵雪完成签到 ,获得积分10
8秒前
星月完成签到 ,获得积分10
8秒前
哈拉少完成签到 ,获得积分10
9秒前
10秒前
11秒前
123发布了新的文献求助10
12秒前
科研通AI2S应助meng采纳,获得10
14秒前
0514gr完成签到,获得积分10
15秒前
yoga完成签到 ,获得积分10
20秒前
21秒前
23秒前
25秒前
深情安青应助shenlee采纳,获得10
25秒前
jia应助优雅的薯片采纳,获得10
25秒前
shanguren发布了新的文献求助10
27秒前
xq1212发布了新的文献求助10
28秒前
施含莲发布了新的文献求助10
29秒前
泡泡龙完成签到 ,获得积分10
29秒前
学术废物完成签到 ,获得积分10
29秒前
Orange应助橘子法则采纳,获得10
30秒前
SCI完成签到,获得积分10
31秒前
33秒前
彭于晏应助食品小帕菜采纳,获得30
33秒前
赘婿应助董世英采纳,获得10
35秒前
科研通AI2S应助LQX2141采纳,获得10
36秒前
LGA1700完成签到,获得积分10
36秒前
shenlee完成签到,获得积分10
36秒前
hahahaha完成签到,获得积分20
38秒前
shenlee发布了新的文献求助10
39秒前
41秒前
Lion完成签到,获得积分10
43秒前
43秒前
郑媛媛发布了新的文献求助60
43秒前
tomato发布了新的文献求助10
46秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200515
求助须知:如何正确求助?哪些是违规求助? 2850286
关于积分的说明 8071642
捐赠科研通 2514122
什么是DOI,文献DOI怎么找? 1346881
科研通“疑难数据库(出版商)”最低求助积分说明 640268
邀请新用户注册赠送积分活动 610349