微生物群
益生菌
益生元
超重
减肥
安慰剂
肠道菌群
菊粉
内科学
肥胖
粪便
生物
生理学
医学
胃肠病学
免疫学
微生物学
食品科学
生物信息学
细菌
病理
遗传学
替代医学
作者
Benjamin H. Mullish,Daryn R. Michael,Julie A. K. McDonald,Giulia Masetti,Sue Plummer,Julian R. Marchesi
出处
期刊:Gut
[BMJ]
日期:2020-04-21
卷期号:70 (1): 225-226
被引量:8
标识
DOI:10.1136/gutjnl-2020-321110
摘要
We read with interest Rodriguez and colleagues’ study, using microbiota transfer from obese stool donors into inulin-treated hum-ob mice, to define a gut microbiome signature predicting response to prebiotic.1 However, the impact of other microbiome-based interventions (and particularly probiotics) on weight loss in humans is highly-variable between individuals.2 We were interested as to whether baseline gut microbiota, or aspects of host physiology, may predict weight loss during probiotic studies.
In our recent double-blind study (ISRCTN12562026), overweight/obese adults were randomised to either 6 months of Lab4P probiotic (containing lactobacilli and bifidobacteria) or placebo.3 A higher proportion of participants receiving probiotic lost weight compared with those receiving placebo, and the extent of weight loss in the probiotic arm was greater than the placebo group.3 We subsequently performed metataxonome and metabonome analysis on stool samples from study participants (using 16S rRNA gene sequencing and liquid chromatography-mass spectrometry bile acid profiling, respectively, applying established protocols4 5).
We observed no difference in stool microbiota alpha-diversity at baseline between participants losing weight during the study versus those who did not (figure 1A); furthermore, no differences were observed in microbiota composition between groups at any taxonomic level. Conversely, on stool bile acid profiling, …
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