镧系元素
发光
镱
材料科学
纳米颗粒
钕
吸收(声学)
钇
铒
钬
纳米技术
兴奋剂
分析化学(期刊)
激光器
光学
化学
光电子学
离子
有机化学
物理
色谱法
冶金
复合材料
氧化物
作者
Meiling Tan,Feng Li,Ning Cao,Hui Li,Xin Wang,Chenyang Zhang,Daniel Jaque,Guanying Chen
出处
期刊:Small
[Wiley]
日期:2020-11-05
卷期号:16 (48)
被引量:94
标识
DOI:10.1002/smll.202004118
摘要
Abstract Luminescence nanothermometry is promising for noninvasive probing of temperature in biological microenvironment at nanometric spatial resolution. Yet, wavelength‐ and temperature‐dependent absorption and scattering of tissues distort measured spectral profile, rendering conventional luminescence nanothermometers (ratiometric, intensity, band shape, or spectral shift) problematic for in vivo temperature determination. Here, a class of lanthanide‐based nanothermometers, which are able to provide precise and reliable temperature readouts at varied tissue depths through NIR‐II luminescence lifetime, are described. To achieve this, an inert core/active shell/inert shell structure of tiny nanoparticles (size, 13.5 nm) is devised, in which thermosensitive lanthanide pairs (ytterbium and neodymium) are spatially confined in the thin middle shell (sodium yttrium fluoride, 1 nm), ensuring being homogenously close to the surrounding environment while protected by the outmost calcium fluoride shell (CaF 2 , ≈2.5 nm) that shields out bioactive milieu interferences. This ternary structure enables the nanothermometers to consistently resolve temperature changes at depths of up to 4 mm in biological tissues, having a high relative temperature sensitivity of 1.4–1.1% °C −1 in the physiological temperature range of 10–64 °C. These lifetime‐based thermosensitive nanoprobes allow for in vivo diagnosis of murine inflammation, mapping out the precise temperature distribution profile of nanoprobes‐interrogated area.
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