转移RNA
生物
计算生物学
蛋白质生物合成
核糖核酸
遗传学
细胞生物学
基因
功能多样性
翻译(生物学)
遗传密码
基因组
进化生物学
作者
Satoshi Kimura,Veerasak Srisuknimit,Matthew K. Waldor
标识
DOI:10.1016/j.mib.2020.06.005
摘要
Transfer RNAs (tRNAs) are non-coding RNAs essential for protein synthesis. tRNAs are heavily decorated with a variety of post-transcriptional modifications (tRNA modifications). Recent methodological advances provide new tools for rapid profiling of tRNA modifications and have led to discoveries of novel modifications and their regulation. Here, we provide an overview of the techniques for investigating tRNA modifications and of the expanding knowledge of their chemistry and regulation.
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