Dietary supplementation with Bacillus mixture modifies the intestinal ecosystem of weaned piglets in an overall beneficial way

回肠 空肠 肠道菌群 生物 益生菌 地衣芽孢杆菌 动物科学 基础(医学) 拟杆菌 食品科学 微生物学 免疫学 枯草芽孢杆菌 生物化学 细菌 内分泌学 遗传学 胰岛素
作者
X. Wang,Zhixi Tian,Md. Abul Kalam Azad,W. Zhang,François Blachier,Wang Zhou,Xiangfeng Kong
出处
期刊:Journal of Applied Microbiology [Oxford University Press]
卷期号:130 (1): 233-246 被引量:29
标识
DOI:10.1111/jam.14782
摘要

Aims This study was conducted to investigate the effects of dietary supplementation with a mixture of Bacillus, which serves as an alternative of antibiotics on the intestinal ecosystem of weaned piglets. Methods and Results We randomly assigned 120 piglets to three groups: a control group (a basal diet), a probiotics group (a basal diet supplemented with 4 × 109 CFU per gram Bacillus licheniformis-Bacillus subtilis mixture; BLS mix), and an antibiotics group (a basal diet supplemented with 0·04 kg t−1 virginiamycin, 0·2 kg t−1 colistin and 3000 mg kg−1 zinc oxide). All groups had five replicates with eight piglets per replicate. On days 7, 21 and 42 of the trial, intestine tissue and digesta samples were collected to determine intestinal morphology, gut microbiota and bacterial metabolite composition, and the expression of genes related to the gut barrier function and inflammatory status. The results showed that the BLS mix decreased the jejunum crypt depth, while increased the ileum villus height and the jejunum and ileum villus height to crypt depth ratio. The BLS mix increased Simpson's diversity index in the gut microbiota and the relative abundances of o_Bacteroidetes and f_Ruminococcaceae, but decreased the relative abundances of Blautia and Clostridium. Dietary BLS mix supplementation also modified the concentration of several bacterial metabolites compared to the control group. In addition, BLS mix upregulated the expression level of E-cadherin in the colon and pro-inflammatory cytokines and TLR-4 in ileum and colon. Lastly, Spearman's rank-order correlation revealed a potential link between alterations in gut microbiota and health parameters of the weaned piglets. Conclusion These findings suggest that dietary BLS mix supplementation modifies the gut ecosystem in weaned piglets. The potential advantages of such modifications in terms of intestinal health are discussed. Significance and Impact of the Study Weaning is the most important transition period of piglet growth and development. This study showed that dietary supplementation of a probiotic mixture of Bacillus, an effective alternative of antibiotics, was beneficial in improving the intestinal ecosystem of weaned piglets.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
加菲完成签到,获得积分10
刚刚
1秒前
丫丫发布了新的文献求助10
1秒前
2秒前
JamesPei应助shinn采纳,获得10
2秒前
4秒前
任性的飞荷关注了科研通微信公众号
5秒前
量子星尘发布了新的文献求助10
5秒前
6秒前
Kuma发布了新的文献求助30
6秒前
慕青应助surge采纳,获得10
6秒前
华仔应助老迟到的沛萍采纳,获得10
6秒前
7秒前
落寞之云发布了新的文献求助10
8秒前
亮亮发布了新的文献求助10
8秒前
九姑娘完成签到 ,获得积分10
9秒前
科研小农民完成签到,获得积分10
9秒前
专注的树发布了新的文献求助10
10秒前
10秒前
欢呼寻冬完成签到 ,获得积分10
10秒前
dorkoom完成签到,获得积分10
10秒前
眰恦完成签到 ,获得积分10
12秒前
12秒前
12秒前
13秒前
13秒前
jessica发布了新的文献求助10
14秒前
乐乐应助落寞之云采纳,获得10
14秒前
英勇的人生完成签到,获得积分10
15秒前
bkagyin应助风清扬采纳,获得10
15秒前
16秒前
17秒前
拼尽全力发布了新的文献求助10
18秒前
17712570999发布了新的文献求助10
18秒前
酷酷的皮皮虾完成签到,获得积分10
18秒前
乐情发布了新的文献求助10
18秒前
19秒前
19秒前
33应助苗条的辣辣采纳,获得10
19秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975250
求助须知:如何正确求助?哪些是违规求助? 3519625
关于积分的说明 11199055
捐赠科研通 3255962
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877358
科研通“疑难数据库(出版商)”最低求助积分说明 806298