医学
效价
外科肿瘤学
内科学
单变量分析
食管癌
临床意义
胃肠病学
基底细胞
抗体效价
肿瘤科
多元分析
抗体
食管鳞状细胞癌
阶段(地层学)
癌症
癌
免疫学
生物
古生物学
作者
Takashi Suzuki,Satoshi Yajima,Akihiko Okamura,Naoya Yoshida,Yusuke Taniyama,Kentaro Murakami,Yu Ohkura,Yasuaki Nakajima,Koichi Yagi,Takashi Fukuda,Ryo Ogawa,Isamu Hoshino,Chikara Kunisaki,Kosuke Narumiya,Yasuhiro Tsubosa,Kazuhiko Yamada,Hideaki Shimada
出处
期刊:Esophagus
[Springer Science+Business Media]
日期:2020-07-26
卷期号:18 (1): 65-71
被引量:20
标识
DOI:10.1007/s10388-020-00761-6
摘要
Although the clinicopathological significance of serum p53 antibodies (s-p53-Abs) in esophageal cancer have been evaluated previously, previous reports only analyzed around 100–200 patients. This study was a multi-institutional study promoted by the Japan Esophageal Society to evaluate the clinical significance of preoperative s-p53-Ab status and antibody titers in 1487 esophageal cancer patients without neoadjuvant therapy. A total of 1487 patients with esophageal squamous cell carcinoma surgically treated between 2008 and 2016 in 15 hospitals in Japan were enrolled. The cut-off value to classify the patients into s-p53-Ab positive and negative groups was 1.30 U/ml. A receiver operating characteristic curve was constructed to assess the s-p53-Abs cut-off levels to differentiate poor prognosis among the s-p53-Ab positive group. Univariate and multivariate analyses were used to evaluate the clinicopathological and prognostic significance of s-p53-Ab status and titers. Although s-p53-Ab status was significantly associated with tumor depth (P = 0.002), nodal status (P = 0.027), and pathological stage (P = 0.002). The s-p53-Ab positive status was not significantly associated with poor overall survival (P = 0.699). Using 9.82 U/ml as a cut-off, the high s-p53-Ab titer group showed a significantly worse overall survival than the low s-p53-Ab titer group (P = 0.038). However, the difference was not significant in the multivariate analysis. The presence of s-p53-Abs was associated with tumor progression. Although high s-p53-Ab titers more than 9.82 U/ml, might be associated with poor prognosis for patients with esophageal squamous cell carcinoma, it was not an independent risk factor.
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