咖啡因
血压
可可碱
心率
山茶
嘌呤
化学
肾上腺素
口服
儿茶酚胺
传统医学
药理学
内科学
医学
生物
植物
生物化学
酶
作者
Shan-Bing Li,Yifang Li,Zhong‐Fu Mao,HU Hui-hua,Rong‐Rong He,Yanping Wu,Bun Tsoi,Pin Gong,Hiroshi Kurihara,Rong‐Rong He
摘要
BACKGROUND Heavy tea consumption is suggested to be unsuitable for hypertensive people. However, the bioactive substances in different varieties of tea leaves are very different. This study compares the effects of three Chinese teas – C. sinensis, C. ptilophylla and C. assamica var. kucha – on blood pressure (BP) and heart rate in spontaneously hypertensive rats (SHRs). RESULTS Intragastric administration of C. sinensis extract led to an acute increase in systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate in SHRs. However, C. ptilophylla and C. assamica var. kucha exerted no obvious influences on SBP, DBP or heart rate. Similar to the extract of C. sinensis, intragastric administration of caffeine also led to an acute increase in BP and heart rate in SHRs. In contrast, theobromine and theacrine – purine alkaloids predominantly contained in C. ptilophylla and C. assamica var. kucha, respectively – had no pressor effects. The effect of caffeine on BP was related to the regulation of plasma epinephrine and norepinephrine levels in SHRs. CONCLUSION The different effects of C. sinensis, C. ptilophylla and C. assamica var. kucha on BP might be explained, at least partially, by the differences in the varieties and contents of purine alkaloids. © 2014 Society of Chemical Industry
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