免疫系统
先天免疫系统
炎症体
免疫学
生物
效应器
获得性免疫系统
受体
干扰素
免疫
功能(生物学)
Ⅰ型干扰素
炎症
细胞生物学
生物化学
作者
José M. González‐Navajas,Jongdae Lee,Michael David,Eyal Raz
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2012-01-06
卷期号:12 (2): 125-135
被引量:863
摘要
Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these cytokines in host defence and homeostasis than was originally assumed. The main focus of this Review is the underappreciated immunomodulatory functions of type I IFNs in health and disease. We discuss their function in the regulation of innate and adaptive immune responses, the response to bacterial ligands, inflammasome activation, intestinal homeostasis and inflammatory and autoimmune diseases.
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