碘海索
医学
病变
碘造影剂
肝细胞
核医学
造影剂
放射科
组织学
病理
计算机断层摄影术
体外
内科学
生物化学
肾功能
化学
作者
Antonina Bergman,A. Sundin,A. Magnusson
标识
DOI:10.1080/02841859709171242
摘要
The iodinated hepatocyte-specific lipid emulsion FP 736-03 for CT of the liver was tested against the conventional water-soluble contrast agent iohexol.A nude rat model of experimental multiple hepatic metastases from a human colonic cancer was used. The animals were examined 3 weeks after intraportal tumor cell injection. Native examination, and iohexol- and FP-736-03-enhanced CT were performed. The detection rate was determined on a lesion-by-lesion basis. Metastatic diameters measured on CT images were compared with corresponding macroscopic serial liver specimens.In a lesion-by-lesion analysis of 140 metastases, the detection rates for 2 viewers were 16.4% and 30.7% for native examination, 12.9% and 17.9% for iohexol-enhanced CT, and 53.6% and 72.1% for FP-736-03-enhanced CT, respectively. The detection rates tended to increase with lesion diameter.The hepatocyte-specific contrast medium FP 736-03 improved the detection rate significantly in comparison with both native and iohexol-enhanced CT.
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